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2-Hydroxycinnamic acid-d4

2-Hydroxycinnamic acid-d4 is deuterium labeled 2-Hydroxycinnamic acid. 2-Hydroxycinnamic acid is a phenolic acid with antimicrobial and antioxidant properties. 2-Hydroxycinnamic acid has antimicrobial activity against Staphylococcus aureus and is not susceptible to drug resistance. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC50 of 0.3 mM. In addition, 2-Hydroxycinnamic acid has neuroprotective and antitumor activity[1][2][3][4][5].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Endogenous Metabolite; HIV; Isotope-Labeled Compounds; SARS-CoV

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Smiles

O=C(O)/C=C/C1=C([2H])C([2H])=C([2H])C([2H])=C1O

Molecular Formula

C9H4D4O3

Molecular Weight

168.18

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Tran Minh Ngoc, et al. A new coumarin and cytotoxic activities of constituents from Cinnamomum cassia. Nat Prod Commun. 2014 Apr;9 (4) :487-8.|[3]Keman D, et al. Antibiotic-Resistant Staphylococcus aureus Does Not Develop Resistance to Vanillic Acid and 2-Hydroxycinnamic Acid after Continuous Exposure in Vitro. ACS Omega. 2019 Sep 10;4 (13) :15393-15400.|[4]Min Zhuang, et al. Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection. Antiviral Res. 2009 Apr;82 (1) :73-81.|[5]Hao S, et al. Hydroxycinnamic Acid from Corncob and Its Structural Analogues Inhibit Aβ40 Fibrillation and Attenuate Aβ40-Induced Cytotoxicity. J Agric Food Chem. 2020 Aug 19;68 (33) :8788-8796.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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