5,5′- (1,3-Propanediyl) bis-1,3,4-oxadiazole-2 (3H) -thione
Selected Variant
HY-141555-01
Size: 1 mg
5,5′- (1,3-Propanediyl) bis-1,3,4-oxadiazole-2 (3H) -thione is a weak inhibitor for snake venom and human recombinant phosphodiesterase 1 with IC50 of 429 and 467 μM. 5,5′- (1,3-Propanediyl) bis-1,3,4-oxadiazole-2 (3H) -thione inhibits mushroom tyrosinase weakly, with Ki of 1.9 μM[1][2].
Product Specifications
CAS Number
333409-31-7
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; Tyrosinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/5-5-1-3-propanediyl-bis-1-3-4-oxadiazole-2-3h-thione.html
Smiles
S=C1OC(CCCC2=NNC(O2)=S)=NN1
Molecular Formula
C7H8N4O2S2
Molecular Weight
244.29
References & Citations
[1]Khan KM, et al., 1,3,4-Oxadiazole-2 (3H) -thione and its analogues: a new class of non-competitive nucleotide pyrophosphatases/phosphodiesterases 1 inhibitors. Bioorg Med Chem. 2009 Nov 15;17 (22) :7816-22. |[2]Ghani U, et al., New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2 (3H) -thiones, 1,3,4-oxadiazole-2 (3H) -thiones, 4-amino-1,2,4-triazole-5 (4H) -thiones, and substituted hydrazides to the dicopper active site. Bioorg Med Chem. 2010 Jun 1;18 (11) :4042-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Price
Sign In for Pricing
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog