5,5′- (1,3-Propanediyl) bis-1,3,4-oxadiazole-2 (3H) -thione
5,5′- (1,3-Propanediyl) bis-1,3,4-oxadiazole-2 (3H) -thione is a weak inhibitor for snake venom and human recombinant phosphodiesterase 1 with IC50 of 429 and 467 μM. 5,5′- (1,3-Propanediyl) bis-1,3,4-oxadiazole-2 (3H) -thione inhibits mushroom tyrosinase weakly, with Ki of 1.9 μM[1][2].
Product Specifications
CAS Number
333409-31-7
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; Tyrosinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/5-5-1-3-propanediyl-bis-1-3-4-oxadiazole-2-3h-thione.html
Smiles
S=C1OC(CCCC2=NNC(O2)=S)=NN1
Molecular Formula
C7H8N4O2S2
Molecular Weight
244.29
References & Citations
[1]Khan KM, et al., 1,3,4-Oxadiazole-2 (3H) -thione and its analogues: a new class of non-competitive nucleotide pyrophosphatases/phosphodiesterases 1 inhibitors. Bioorg Med Chem. 2009 Nov 15;17 (22) :7816-22. |[2]Ghani U, et al., New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2 (3H) -thiones, 1,3,4-oxadiazole-2 (3H) -thiones, 4-amino-1,2,4-triazole-5 (4H) -thiones, and substituted hydrazides to the dicopper active site. Bioorg Med Chem. 2010 Jun 1;18 (11) :4042-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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