11R (12S) -EET

11R (12S) -EET is a cis-epoxytrienoic acid (EETs) derivative that is metabolized by cytoplasmic cyclooxygenases. Studies have shown that 14 (R), 15 (S) -, 11 (S),12 (R) -, and 8 (S),9 (R) -EETs are metabolized at significantly higher rates than their enantiomers. Enzyme-catalyzed hydration revealed that water addition was non-regioselective for the 11,12-EET enantiomers, whereas water addition occurred primarily at the C9 position for both enantiomers of 8,9-EET. These results suggest that the metabolic properties of 11R (12S) -EET and other EET enantiomers in enzyme-catalyzed processes are significantly affected by their stereostructures[1].

Product Specifications

CAS Number

[123931-38-4]

UNSPSC

12352005

Target

Others

Type

Natural Products

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/11r-12s-eet.html

Smiles

OC(CCC/C=C\C/C=C\C[C@@H]1[C@@H](O1)C/C=C\CCCCC)=O

Molecular Formula

C20H32O3

Molecular Weight

320.47

References & Citations

[1]Zeldin DC, et al. Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis. Arch Biochem Biophys. 1995 Jan 10;316 (1) :443-51.