11R (12S) -EET

11R (12S) -EET is a cis-epoxytrienoic acid (EETs) derivative that is metabolized by cytoplasmic cyclooxygenases. Studies have shown that 14 (R), 15 (S) -, 11 (S),12 (R) -, and 8 (S),9 (R) -EETs are metabolized at significantly higher rates than their enantiomers. Enzyme-catalyzed hydration revealed that water addition was non-regioselective for the 11,12-EET enantiomers, whereas water addition occurred primarily at the C9 position for both enantiomers of 8,9-EET. These results suggest that the metabolic properties of 11R (12S) -EET and other EET enantiomers in enzyme-catalyzed processes are significantly affected by their stereostructures[1].