ME-143
ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo[1].
Product Specifications
CAS Number
[852536-39-1]
Product Name Alternative
NV-143
UNSPSC
12352005
Target
Endogenous Metabolite; Wnt
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/me-143.html
Purity
99.01
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=CC=C2C(C3=CC=C(O)C=C3)C(C4=CC=C(O)C=C4)COC2=C1
Molecular Formula
C21H18O4
Molecular Weight
334.37
References & Citations
[1]Pintova S, et al. ME-143 Is Superior to Genistein in Suppression of WNT Signaling in Colon Cancer Cells. Anticancer Res. 2017;37 (4) :1647-1653.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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