Sheep anti Human Cytochrome c

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain._x000B_Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases._x000B_Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.

Applications: Western Blot 1:5,000, shows a MW of 14.4kDa. May be used in immunofluorescence applications with Human and rat cells; Immunoprecipitation - Empirical.

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

1. Morison, I.M., et al. 'A mutation of Human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia.' Nat. Genet. 2008, 40, 387-389 2. Skulachev, V.P. 'Cytochrome c is the apoptotic and antioxidant cascades.’ FEBS Lett 1998, 423, 275-280