Baohuoside I
Baohuoside I, a flavonoid isolated from Epimedium koreanum Nakai, acts as an inhibitor of CXCR4, downregulates CXCR4 expression, induces apoptosis and shows anti-tumor activity.
Product Specifications
CAS Number
113558-15-9
Product Name Alternative
Icariin-II; Icariside-II
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; CXCR
Type
Natural Products
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Baohuoside-I.html
Concentration
10mM
Purity
99.94
Solubility
DMSO : ≥ 32 mg/mL
Smiles
OC1=CC(O)=C2C(OC(C3=CC=C(OC)C=C3)=C(O[C@H](O[C@@H](C)[C@H](O)[C@H]4O)[C@@H]4O)C2=O)=C1C/C=C(C)\C
Molecular Formula
C27H30O10
Molecular Weight
514.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Kim B, et al. Baohuoside I suppresses invasion of cervical and breast cancer cells through the downregulation of CXCR4 chemokine receptor expression. Biochemistry. 2014 Dec 9;53 (48) :7562-9.|[2]Song J, et al. Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis in human non-small cell lung cancer. Chem Biol Interact. 2012 Jul 30;199 (1) :9-17.|[3]Wang L, et al. The flavonoid Baohuoside-I inhibits cell growth and downregulates survivin and cyclin D1 expression in esophageal carcinoma via β-catenin-dependent signaling. Oncol Rep. 2011 Nov;26 (5) :1149-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CXCR4
Available Sizes
Frequently Asked Questions
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