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Meclofenamic acid-d4

Meclofenamic acid-d4 is the deuterium labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m (6) A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker[1][2][3].

Product Specifications

CAS Number

1185072-18-7

Product Name Alternative

Meclofenamate-d4

UNSPSC

12352005

Target

Endogenous Metabolite; Gap Junction Protein; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Cytoskeleton; Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

ClC(C(C)=CC=C1Cl)=C1NC2=C(C([2H])=C([2H])C([2H])=C2[2H])C(O)=O

Molecular Formula

C14H7D4Cl2NO2

Molecular Weight

300.17

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8.|[3]Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017.|[4]Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43 (1) :373-84.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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