PPARγ agonist 12
PPARγ agonist 12 (compound 9i) is a potent and selective PPARγ agonist with EC50s of 3.98 and 15.42 μM against PPARγ and PPARδ, respectively. PPARγ agonist 12 improves insulin secretion and has anti-diabetic effect[1].
Product Specifications
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pparγ-agonist-12.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(NC2=NC(/C(S2)=C\C3=CC(OC)=C(OCC4=CC(OC)=CC=C4)C=C3)=O)C=C1)(N)=O
Molecular Formula
C25H23N3O6S2
Molecular Weight
525.60
References & Citations
[1]Ali I H, et al. Novel thiazolidin-4-one benzenesulfonamide hybrids as PPARγ agonists: Design, synthesis and In vivo anti-diabetic evaluation[J]. European Journal of Medicinal Chemistry, 2024: 116279.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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