Desethyl chloroquine (Standard)
Product Specifications
UNSPSC Description
Desethyl chloroquine (Standard) is the analytical standard of Desethyl chloroquine. This product is intended for research and analytical applications. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].
Target Antigen
Autophagy; Parasite; Toll-like Receptor (TLR)
Type
Reference Standards
Related Pathways
Anti-infection;Autophagy;Immunology/Inflammation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/desethyl-chloroquine-standard.html
Smiles
CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCC
Molecular Weight
291.82
References & Citations
[1]Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100.|[2]Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74.|[3]Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-135811R/Desethyl-chloroquine-Standard-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-135811R/
CAS Number
1476-52-4
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