Aladotril

Aladotril (BP1137) is the inhibitor for neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE), that ameliorates the cardiac hypertrophy in rats, without decreasing the blood pressure. Aladotril can be used in research about heart failure and cardiac remodeling after myocardial infarction[1].

Product Specifications

CAS Number

[173429-64-6]

Product Name Alternative

BP1137

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE) ; Neprilysin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/aladotril.html

Smiles

O=C(OCC1=CC=CC=C1)[C@H](C)NC([C@@H](CS)CC2=CC=C(OCO3)C3=C2)=O

Molecular Formula

C21H23NO5S

Molecular Weight

401.48

References & Citations

[1]Marie C, et al., Effect of long-term therapy with fasidotril, a mixed inhibitor of neprilysin and angiotensin-converting enzyme (ACE), on survival of rats after myocardial infarction. Cardiovasc Res. 1999 Mar;41 (3) :544-53.