Aladotril
Aladotril (BP1137) is the inhibitor for neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE), that ameliorates the cardiac hypertrophy in rats, without decreasing the blood pressure. Aladotril can be used in research about heart failure and cardiac remodeling after myocardial infarction[1].
Product Specifications
CAS Number
173429-64-6
Product Name Alternative
BP1137
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE) ; Neprilysin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/aladotril.html
Smiles
O=C(OCC1=CC=CC=C1)[C@H](C)NC([C@@H](CS)CC2=CC=C(OCO3)C3=C2)=O
Molecular Formula
C21H23NO5S
Molecular Weight
401.48
References & Citations
[1]Marie C, et al., Effect of long-term therapy with fasidotril, a mixed inhibitor of neprilysin and angiotensin-converting enzyme (ACE), on survival of rats after myocardial infarction. Cardiovasc Res. 1999 Mar;41 (3) :544-53.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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