PF-07899895
PF-07899895 (compound 34) is a SIK inhibitor, with IC50 values of 1.2 nM, 0.9 nM and 1.8 nM for SIK1, SIK2 and SIK3, respectively[1].
Product Specifications
CAS Number
[3033846-10-2]
UNSPSC
12352005
Target
Salt-inducible Kinase (SIK)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/sik-in-4.html
Purity
98.83
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N#CC1=CC=CC2=NC=C(N12)C3=CC(SC)=C(C#N)C(OCC4(CCCCC4)N)=C3
Molecular Formula
C23H23N5OS
Molecular Weight
417.53
References & Citations
[1]Andrea Nicole BOOTSMA, et al. Heterocyclic sik inhibitors. Patent WO2024062360.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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