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Anti-Endothelin Antibody

Mouse Monoclonal Antibody specific to Endothelin

Product Specifications

Product Name Alternative

Preproendothelin-1, PPET1 [Cleaved into: Endothelin-1

Gene Name

EDN1

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=EDN1">EDN1</a>

UniProt

P05305

Cellular Locus

Secreted.

Host

Mouse

Reactivity

Human

Immunogen

Human endothelin-1 (ET-1)

Target Antigen

Endothelin-1

Target

Endothelin

Clonality

Monoclonal

Isotype

IgG1

Type

Antibody

Applications

ELISA, WB, IHC

Field of Research

Hormones/Proteins

Purification Method

Purified by Protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437). {UniProtKB:P09558, PubMed:17446437, PubMed:19086031}.

Additionnal Information

<br><br>Immunohistochemistry:Paraffin-embedded rat kidney exposed to 60 minutes of ischemia. ET-1 expression is seen in the endothelium of the peritubular capillary network (arrows, dark reaction product) with #19401 at 5-20ug/ml. Wilhelm SM et al. 1999 Kidney International 55: 1011-1018.ELISA:use at 5-20ug/ml with endothelin-1 on the solid phase. <br><br>These are recommended concentrations. <br><br>Endusers should determine optimal concentrations for their applications.

Storage Conditions

These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/19401-19404.pdf

Specificity

Human endothelin-1 (ET-1).

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

CAS Number

9007-83-4

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