6-Hydroxy bexarotene
6-Hydroxy bexarotene is the main circulating metabolite of bexarotene, found in rats, dogs, and humans. Compared to the parent compound, 6-hydroxy-bexarotene shows a significantly reduced ability to bind to retinoid receptors and exhibits very minimal activity in activating retinoic acid receptors[1].
Product Specifications
CAS Number
368451-07-4
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/6-hydroxy-bexarotene.html
Smiles
CC1=CC2=C(C(C)(CC(C2(C)C)O)C)C=C1C(C3=CC=C(C=C3)C(O)=O)=C
Molecular Formula
C24H28O3
Molecular Weight
364.48
References & Citations
[1]S R Howell, et al. Bexarotene metabolism in rat, dog, and human, synthesis of oxidative metabolites, and in vitro activity at retinoid receptors. Drug Metab Dispos. 2001 Jul;29 (7) :990-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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