Antitumor agent-180
Antitumor agent-180 (Compound 13a) is an inhibitor for BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) . Antitumor agent-180 inhibits the proliferation of ccRCC cell Caki-1 with IC50 of 2.047 µM. Antitumor agent-180 induces necrosis and apoptosis in Caki-1[1].
Product Specifications
CAS Number
[9007-83-4]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-180.html
Purity
99.46
Smiles
CN(CC1)CCN1C2=CC=C(NC3=C(C)C=NC(NC4=CC=C(C(NC5=CC=C(N6CCN(C)CC6)C=C5)=O)C=C4)=N3)C=C2
Molecular Formula
C34H41N9O
Molecular Weight
591.75
References & Citations
[1]Bouzian Y, et al., Design and evaluation of novel inhibitors for the treatment of clear cell renal cell carcinoma. Bioorg Chem. 2024 Jul 6;151:107597.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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