BRD5648

BRD5648 ((R) -BRD0705) is a negative control of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM) . BRD0705 can be used for acute myeloid leukemia (AML) [1][2].

Product Specifications

CAS Number

[2056261-42-6]

Product Name Alternative

(R) -BRD0705

UNSPSC

12352005

Target

GSK-3

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/brd5648.html

Purity

99.94

Solubility

DMSO : 300 mg/mL (ultrasonic)

Smiles

O=C1C2=C(N=C3C([C@@]2(CC)C4=CC=CC=C4)=CNN3)CC(C)(C)C1

Molecular Formula

C20H23N3O

Molecular Weight

321.42

References & Citations

[1]Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10 (431) . pii: eaam8460.