What is the catalog number for GW9508?

The catalog number for GW9508 is HY-15589.

What sizes are available for GW9508?

GW9508 is available in the following size(s): 5 mg, 10 mg, 10 mM - 1 mL, 50 mg, 100 mg.

How many pack sizes does GW9508 come in?

GW9508 is available in 5 different pack sizes.

GW9508 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures GW9508?

GW9508 is manufactured by QuantiMol.

What is the estimated delivery time for GW9508?

Estimated delivery time for GW9508 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for GW9508?

The safety data sheet for GW9508 is available here: http://file.medchemexpress.com/batch_PDF/HY-15589/GW9508-SDS-MedChemExpress.pdf.

GW9508

GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities[1][2][3][4].

Product Specifications

CAS Number

885101-89-3

UNSPSC

12352005

Hazard Statement

H302, H315, H318, H335, H410

Target

Free Fatty Acid Receptor; Potassium Channel

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/GW9508.html

Purity

99.23

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(O)CCC1=CC=C(NCC2=CC=CC(OC3=CC=CC=C3)=C2)C=C1

Molecular Formula

C22H21NO3

Molecular Weight

347.41

Precautions

H302, H315, H318, H335, H410

References & Citations

[1]Briscoe CP, et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol. 2006 Jul;148 (5) :619-28.|[2]Zhao YF, et al. Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. J Endocrinol, 2008, 198 (3), 533-540.|[3]Fujita T, et al. A GPR40 agonist GW9508 suppresses CCL5, CCL17, and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation. J Invest Dermatol, 2011, 131 (8), 1660-1667.|[4]Suski M, et al. Anti-atherosclerotic action of GW9508 - Free fatty acid receptors activator - In apoE-knockout mice. Pharmacol Rep. 2019 Aug;71 (4) :551-555.