CDK-IN-2
CDK-IN-2 is a specific CDK9 inhibitor with an IC50 of less than 8 nM. CDK-IN-2 reduces the phosphorylation level of H3S10. CDK-IN-2 decreases the transition rate of spermatocytes from prophase to metaphase I[1][2].
Product Specifications
CAS Number
1269815-17-9
Product Name Alternative
CDK inhibitor II
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/CDK-IN-2.html
Concentration
10mM
Purity
99.27
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC1=CC(C2=CC(NC([C@H]3CNCCC3)=O)=NC=C2Cl)=C(C=C1)OC
Molecular Formula
C18H19ClFN3O2
Molecular Weight
363.81
Precautions
H302, H315, H319, H335
References & Citations
[1]Keith B Pfister, et al. Heteroaryl compounds as kinase inhibitors. 2011, WO2011026917A1.|[2]Li H, et al. Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse. Cell Mol Life Sci. 2022 Aug 5;79 (8) :467.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9
Available Sizes
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