CDK-IN-2

CDK-IN-2 is a specific CDK9 inhibitor with an IC50 of less than 8 nM. CDK-IN-2 reduces the phosphorylation level of H3S10. CDK-IN-2 decreases the transition rate of spermatocytes from prophase to metaphase I[1][2].

Product Specifications

CAS Number

[1269815-17-9]

Product Name Alternative

CDK inhibitor II

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/CDK-IN-2.html

Concentration

10mM

Purity

99.27

Solubility

DMSO : ≥ 100 mg/mL

Smiles

FC1=CC(C2=CC(NC([C@H]3CNCCC3)=O)=NC=C2Cl)=C(C=C1)OC

Molecular Formula

C18H19ClFN3O2

Molecular Weight

363.81

Precautions

H302, H315, H319, H335

References & Citations

[1]Keith B Pfister, et al. Heteroaryl compounds as kinase inhibitors. 2011, WO2011026917A1.|[2]Li H, et al. Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse. Cell Mol Life Sci. 2022 Aug 5;79 (8) :467.