AUNP-12
AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs) [1].
Product Specifications
CAS Number
1353563-85-5
Product Name Alternative
NP-12
UNSPSC
12352209
Hazard Statement
H302, H400, H410
Target
PD-1/PD-L1
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/np-12.html
Purity
99.31
Solubility
H2O : 10 mg/mL (ultrasonic)
Smiles
OC(CC[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@H](C)NC([C@H](CCCCN)NC([C@H]1N(CCC1)C([C@H](C)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCCNC([C@@H](NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC(N)=O)NC([C@@H](N)CO)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)NC([C@@H](NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC(N)=O)NC([C@@H](N)CO)=O)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C142H226N40O48
Molecular Weight
3261.55
Precautions
H302, H400, H410
References & Citations
[1]Sasikumar PG, et al. A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy. Mol Cancer Ther. 2019 Jun;18 (6) :1081-1091.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![(8R,9R)-8,9-Dihydrobenz[a]anthracene-8,9-diol Dibenzoate](https://cdn.genprice.uk/products/572/7159866216615/imageurl/trc-d452985-5mg.webp)
TRC-D452985-5MG 5 mg
(8R,9R)-8,9-Dihydrobenz[a]anthracene-8,9-diol Dibenzoate
Sign In for Pricing
View Details 
![ASS1 Mouse Monoclonal Antibody [Clone ID: OTI14C1]](https://cdn.genprice.uk/products/937/68dd18ba061270361e9084ec/imageurl/cf809140.webp)
BNC882172-500 1x 500 µL
Ep-CAM / CD326 (Extracellular Domain) (Epithelial Marker) (rEGP40/1372), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 