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Flurbiprofen-d4

Flurbiprofen-d4 is deuterated labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].

Product Specifications

Product Name Alternative

Dl-Flurbiprofen-d4

UNSPSC

12352005

Target

Apoptosis; COX; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Immunology/Inflammation; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

FC1=C(C2=CC=CC=C2)C=CC(C([2H])(C([2H])([2H])[2H])C(O)=O)=C1

Molecular Formula

C15H9D4FO2

Molecular Weight

248.29

References & Citations

[1]Hosoi, T., et al., Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med, 2014.|[2]Xiaobo Wang, et al. Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2. Oncol Lett. 2020 Nov; 20 (5) : 132.|[3]E M Glenn, et al. The pharmacology of 2- (2-fluoro-4-biphenylyl) propionic acid (flurbiprofen) . A potent non-steroidal anti-inflammatory drug. Agents Actions. 1973 Nov;3 (4) :210-6.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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