Silatecan
Product Specifications
UNSPSC Description
Silatecan (AR-67; DB 67) is a Camptothecin (HY-16560) analogue with improved stability and lipophilicity. Silatecan is an inhibitor for topoisomerase I, that inhibits the DNA replication and transcription, and exhibits antitumor and radiosensitizing activities[1]
Target Antigen
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/silatecan.html
Smiles
O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C([Si](C)(C(C)(C)C)C)C5=CC(O)=CC=C5N=C4C3=C2)=O
Molecular Weight
478.61
References & Citations
[1]Chen A Y, et al. Silatecan DB-67 is a novel DNA topoisomerase I–targeted radiation sensitizer[J]. Molecular cancer therapeutics, 2005, 4(2): 317-324.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16055/Silatecan-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16055/
Clinical Information
Phase 2
CAS Number
220913-32-6
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