Silatecan

Silatecan (AR-67; DB 67) is a Camptothecin (HY-16560) analogue with improved stability and lipophilicity. Silatecan is an inhibitor for topoisomerase I, that inhibits the DNA replication and transcription, and exhibits antitumor and radiosensitizing activities[1]

Product Specifications

CAS Number

[220913-32-6]

Product Name Alternative

AR-67; DB 67

UNSPSC

12352005

Hazard Statement

H301

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/silatecan.html

Smiles

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C([Si](C)(C(C)(C)C)C)C5=CC(O)=CC=C5N=C4C3=C2)=O

Molecular Formula

C26H30N2O5Si

Molecular Weight

478.61

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Chen A Y, et al. Silatecan DB-67 is a novel DNA topoisomerase I–targeted radiation sensitizer[J]. Molecular cancer therapeutics, 2005, 4 (2) : 317-324.