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Chlorpheniramine (maleate) (Standard)

Chlorpheniramine (maleate) (Standard) is the analytical standard of Chlorpheniramine (maleate) . This product is intended for research and analytical applications. Chlorpheniramine maleate is a histamine H1 receptor antagonist with an IC50 of 12 nM[1][2][3].

Product Specifications

CAS Number

113-92-8

Product Name Alternative

Chlorphenamine maleate (Standard)

UNSPSC

12352005

Hazard Statement

H302

Target

Histamine Receptor; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/chlorpheniramine-maleate-standard.html

Purity

99.37

Smiles

CN(C)CCC(C1=CC=C(Cl)C=C1)C2=CC=CC=N2.O=C(O)/C=C\C(O)=O

Molecular Formula

C20H23ClN2O4

Molecular Weight

390.86

Precautions

H302

References & Citations

[1]Medina, M.A., et al., Chlorpheniramine inhibits the synthesis of ornithine decarboxylase and the proliferation of human breast cancer cell lines. Breast Cancer Res Treat, 1995. 35 (2) : p. 187-94.|[2]Kelly, J.X., et al., Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother, 2007. 51 (11) : p. 4133-40.|[3]Iemura, R., et al., Synthesis of 2- (4-substituted-1-piperazinyl) benzimidazoles as H1-antihistaminic agents. J Med Chem, 1986. 29 (7) : p. 1178-83.|[4]Takano, N., I. Arai, and M. Kurachi, Analysis of the spontaneous scratching behavior by NC/Nga mice: a possible approach to evaluate antipruritics for subjects with atopic dermatitis. Eur J Pharmacol, 2003. 471 (3) : p. 223-8.|[5]Kim J, et al. Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells. Eur J Pharmacol. 2017 Mar 5;798:122-128.

Shipping Conditions

Room Temperature

Storage Conditions

4°C, sealed and dry storage, away from light and moisture

Scientific Category

Reference Standards

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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