L134
L134 is a potent PROTAC BRD4 degrader with a DC50 value of 7.36 nM. L134 mediates the degradation of BRD4 via the ubiquitin-proteasome system in a DCAF11-dependent manner (Blue: JQ-1 (carboxylic acid) , Black: linker (HY-W004640) ; Pink: E3 ligase ligand, L321 (HY-169359) ).
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l134.html
Purity
99.37
Smiles
CC1=CC=C(C(/C=C2C(NC3=C\2C=CC(C(F)(F)F)=C3)=O)=C1)OCC(NCCCOCCOCCOCCCNC(C[C@@H]4N=C(C5=C(N6C4=NN=C6C)SC(C)=C5C)C7=CC=C(C=C7)Cl)=O)=O
Molecular Formula
C48H51ClF3N7O7S
Molecular Weight
962.47
References & Citations
[1]Man Zhao, et al. Design, Synthesis, and Activity Evaluation of BRD4 PROTAC Based on Alkenyl Oxindole-DCAF11 Pair. J Med Chem. 2024 Nov 14;67 (21) :19428-19447.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; Cereblon
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC402992-500 1x 500 µL
MUC3 (Mucin 3) (MUC3/2992R), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
![CEP72 Mouse Monoclonal Antibody [Clone ID: OTI1B8]](https://cdn.genprice.uk/products/937/68dd18bb061270361e908a60/imageurl/cf811141.webp)
BNC472674-100 1x 100 µL
CD117 / c-Kit (Marker for Gastrointestinal Stromal Tumors) (KIT/2674), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
P014-APC-125 1x 125 µL
CD81 Recombinant Monoclonal Mouse Antibody (2304.81), APC Conjugate - Biotium Choice
Sign In for Pricing
View Details