Mirodenafil (dihydrochloride)

Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) [1][2][3].

Product Specifications

CAS Number

[862189-96-6]

Product Name Alternative

SK-3530 dihydrochloride

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Glucocorticoid Receptor; Phosphodiesterase (PDE) ; Wnt; β-catenin

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Mirodenafil-dihydrochloride.html

Purity

99.85

Solubility

DMSO : ≥ 100 mg/mL|H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[H]Cl.[H]Cl.O=C1C(N(CC)C=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(CCO)CC4)=O)=CC=C3OCCC)N1

Molecular Formula

C26H39Cl2N5O5S

Molecular Weight

604.59

Precautions

P264-P270-P330-P501

References & Citations

[1]Park HJ, et al. Mirodenafil for the treatment of erectile dysfunction: a systematic review of the literature. World J Mens Health. 2014 Apr;32 (1) :18-27.|[2]Kang BW, et al. Phosphodiesterase 5 inhibitor mirodenafil ameliorates Alzheimer-like pathology and symptoms by multimodal actions. Alzheimers Res Ther. 2022 Jul 8;14 (1) :92.|[3]Roh JS, et al. Mirodenafil ameliorates skin fibrosis in bleomycin-induced mouse model of systemic sclerosis. Anim Cells Syst (Seoul) . 2021 Nov 3;25 (6) :387-395.