SCD1 inhibitor-1
SCD1 inhibitor-1 (Compound 48) is an orally active and liver-selective inhibitor of stearoyl-CoA desaturase 1 (SCD1) with an IC50 of 8.8 nM for recombinant human SCD1 enzyme. SCD1 inhibitor-1 can be used in the study of diseases such as diabetes, hepatic steatosis and obesity[1].
Product Specifications
CAS Number
1069094-65-0
UNSPSC
12352005
Target
Stearoyl-CoA Desaturase (SCD)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/scd1-inhibitor-1.html
Purity
99.91
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC(CC(O[Na])=O)=CS1)C(S2)=CC=C2CNC3=CC=CC=C3CCCC
Molecular Formula
C21H22N3NaO3S2
Molecular Weight
451.54
References & Citations
[1]Iida T, et al. Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity. Eur J Med Chem. 2018 Oct 5;158:832-852.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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