3-Indoleacetonitrile

3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV[1][2].

Product Specifications

CAS Number

[771-51-7]

UNSPSC

12352005

Hazard Statement

H301, H311, H331

Target

Endogenous Metabolite; HSV; Influenza Virus; VSV

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/3-indoleacetonitrile.html

Purity

99.93

Solubility

DMSO : 100 mg/mL|H2O : 1 mg/mL (ultrasonic)

Smiles

N#CCC1=CNC2=C1C=CC=C2

Molecular Formula

C10H8N2

Molecular Weight

156.19

Precautions

H301, H311, H331

References & Citations

[1]Zhao, X., et al., (2021) . 3-Indoleacetonitrile Is Highly Effective in Treating Influenza A Virus Infection In Vitro and In Vivo. Viruses, 13 (8), 1433. |[2]Hui, X., et al., (2023) . In vitro and in vivo effects of 3-indoleacetonitrile-A potential new broad-spectrum therapeutic agent for SARS-CoV-2 infection. Antiviral research, 209, 105465.