HDHODH-IN-15
HDHODH-IN-15 (Compound H19) is an inhibitor for human dihydroguanylate dehydrogenase (hDHODH) with an IC50 of 0.21 µM. hDHODH-IN-15 exhibits cytotoxicity in cancer cells NCI-H226, HCT-116, and MDA-MB-231, with IC50 of 0.95-2.81 µM. hDHODH-IN-15 induces ferroptosis in HCT-116, and exhibits antitumor efficacy[1].
Product Specifications
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdhodh-in-15.html
Smiles
C#CC(N1CCN(CC1)C(/C=C/C=C/C2=CC3=C(OCO3)C=C2)=O)=O
Molecular Formula
C19H18N2O4
Molecular Weight
338.36
References & Citations
[1]Zhang JF, et al., Discovery of piperine derivatives as inhibitors of human dihydroorotate dehydrogenase to induce ferroptosis in cancer cells. Bioorg Chem. 2024 Sep;150:107594.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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