Melanoma Marker (MART-1 + gp100) (DT101+ BC199 + HMB45), 0.2mg/mL
This antibody cocktail recognizes two melanoma-specific proteins, which include MART-1 and gp100. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Function of gp100 is not known but it is reported to be a useful marker for melanocytes and melanomas. A cocktail of these two markers is sensitive for labeling formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.
Product Specifications
CAS Number
9007-83-4
Synonyms
Melanoma antigen recognized by T-cells 1 (MART-1), MLAN-A; PMEL17
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
MLANA; SILV
Gene ID
2315; 6490
NCBI Gene ID
154069 ; 95972
UniProt
Q16655; P40967
Swiss Prot
Q16655 ; P40967
Host
Mouse
Species Reactivity
Human
Reactivity
Melanoma cells
Immunogen
Recombinant hMART-1 protein (DT101 & BC199) ; Extract of pigmented melanoma metastases from lymph nodes (HMB45)
Target Antigen
Melanoma cells
Clonality
Monoclonal
Clone
DT101 BC199 HMB45
Type
Primary
Source
Animal
Origin
Animal
Applications
IHC, FFPE (verified)
Field of Research
Cancer
Positive Control
SK-MEL-13 and SK-MEL-19 melanoma cell lines. Human melanoma tissues.
Stability
2 years
Concentration
0.2 mg/mL
Buffer
PBS, 0.05% BSA, 0.05% azide
Molecular Weight
20-22 kDa (doublet) (MART-1) ; 90-100 kDa (gp100)
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG1, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate
Purified, with BSA
Documents
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