TCO-PEG3-alcohol

TCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG3-alcohol is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

Product Specifications

CAS Number

[1955497-82-1]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tco-peg3-alcohol.html

Purity

99.32

Solubility

10 mM in DMSO

Smiles

O=C(NCCOCCOCCOCCO)OC1CC/C=C\CCC1

Molecular Formula

C17H31NO6

Molecular Weight

345.43

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562