Procyclidine

Procyclidine (Tricyclamol; (±) -Procyclidine), an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy[1][2].

Product Specifications

CAS Number

[77-37-2]

Product Name Alternative

Tricyclamol; (±) -Procyclidine

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

IGluR; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/procyclidine.html

Solubility

10 mM in DMSO

Smiles

OC(C1=CC=CC=C1)(C2CCCCC2)CCN3CCCC3

Molecular Formula

C19H29NO

Molecular Weight

287.44

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1] Yun-Bae Kim, et al. Effects of combinational prophylactics composed of physostigmine and procyclidine on soman-induced lethality, seizures and brain injuries. Environ Toxicol Pharmacol. 2002 Jan;11 (1) :15-21.|[2]Ulrich Ettinger, et al. Effects of procyclidine on eye movements in schizophrenia. Neuropsychopharmacology. 2003 Dec;28 (12) :2199-208.