6-Diazo-5-oxo-L-nor-Leucine
Product Specifications
UNSPSC Description
6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity[1][2][3].
Target Antigen
Antibiotic; Bacterial; Glutaminase; Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/6-diazo-5-oxo-l-nor-leucine.html
Purity
99.98
Solubility
H2O : 25 mg/mL (ultrasonic)
Smiles
N[C@@H](CCC(C=[N+]=[N-])=O)C(O)=O
Molecular Weight
171.15
References & Citations
[1]Willis RC, et al. The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast. J Cell Physiol. 1977 Dec;93(3):375-82.|[2]Sharma NS, et al. Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy. J Clin Invest. 2019 Oct 15.|[3]DeWald H A, et al. 6-diazo-5-oxo-l-norleucine, a new tumor-inhibitory substance. 1a preparation of l-, d-and dl-forms1b. Journal of the American Chemical Society, 1958, 80(15): 3941-3945.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-108357/6-Diazo-5-oxo-L-nor-Leucine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-108357/6-Diazo-5-oxo-L-nor-Leucine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
157-03-9
Available Sizes
Curated Selection
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