6-Diazo-5-oxo-L-nor-Leucine
6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity[1][2][3].
Product Specifications
CAS Number
[157-03-9]
Product Name Alternative
L-6-Diazo-5-oxonorleucine; DON
UNSPSC
12352211
Hazard Statement
H301+H311+H331
Target
Antibiotic; Bacterial; Glutaminase; Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/6-diazo-5-oxo-l-nor-leucine.html
Purity
99.98
Solubility
H2O : 25 mg/mL (ultrasonic)
Smiles
N[C@@H](CCC(C=[N+]=[N-])=O)C(O)=O
Molecular Formula
C6H9N3O3
Molecular Weight
171.15
Precautions
H301+H311+H331
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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