Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Azadirachtin

Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting Bcl-2/Bax ratio or activating Apaf-1 and caspase-3) or through death receptors (by inhibiting TNFR activation) . Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-кB signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells[1][2][3][4][5][6].

Product Specifications

UNSPSC

12352005

Hazard Statement

H317, H410

Target

Apoptosis; Bcl-2 Family; Caspase; NF-κB; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; NF-κB

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/azadirachtin.html

Purity

99.06

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C[C@@]1([C@@]([C@@]2(O)C(OC)=O)([H])[C@]([C@H](C[C@H]3OC(C)=O)OC(/C(C)=C/C)=O)(CO2)[C@@]4([H])[C@](OC[C@@]43C(OC)=O)([H])[C@H]1O)[C@]([C@@H](O[C@]5([H])OC=C6)C[C@H]7[C@]56O)(O8)[C@]78C

Molecular Formula

C35H44O16

Molecular Weight

720.71

Precautions

H317, H410

References & Citations

[1]Shu B, Jia J, Zhang J, Sethuraman V, Yi X, Zhong G. DnaJ homolog subfamily A member1 (DnaJ1) is a newly discovered anti-apoptotic protein regulated by azadirachtin in Sf9 cells. BMC Genomics. 2018;19 (1) :413. Published 2018 May 29.|[2]Fernandes SR, et al. Chemistry, bioactivities, extraction and analysis of azadirachtin: State-of-the-art. Fitoterapia. 2019 Apr;134:141-150.|[3]Thoh M, et al. Azadirachtin interacts with retinoic acid receptors and inhibits retinoic acid-mediated biological responses. J Biol Chem. 2011 Feb 11;286 (6) :4690-702. doi: 10.1074/jbc.M110.169334. Epub 2010 Dec 2. Retraction in: J Biol Chem. 2013 Mar 22;288 (12) :8563. |[4]Priyadarsini RV, et al. The neem limonoids azadirachtin and nimbolide inhibit hamster cheek pouch carcinogenesis by modulating xenobiotic-metabolizing enzymes, DNA damage, antioxidants, invasion and angiogenesis. Free Radic Res. 2009 May;43 (5) :492-504.|[5]Priyadarsini RV, et al. The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells.|[6]Tapanelli S, et al. Transmission blocking effects of neem (Azadirachta indica) seed kernel limonoids on Plasmodium berghei early sporogonic development. Fitoterapia. 2016 Oct;114:122-126.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-126741/Azadirachtin-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-126741/Azadirachtin-SDS-MedChemExpress.pdf

Scientific Category

Natural Products

Clinical Information

Phase 2

Isoform

Caspase 3

CAS Number

[11141-17-6]

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Gabrr3 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
21170114 3 x 1.0 µg

Gabrr3 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

Ask
View Details
Slc18a2 Mouse shRNA Lentiviral Particle (Locus ID 214084)
TL513606V 500 µL Each

Slc18a2 Mouse shRNA Lentiviral Particle (Locus ID 214084)

Ask
View Details
Tomm7-set siRNA/shRNA/RNAi Lentivector (Rat)
47298096 4 x 500 ng

Tomm7-set siRNA/shRNA/RNAi Lentivector (Rat)

Ask
View Details
MIR183 Rat MicroRNA Expression Plasmid (MI0000928)
SC403178 10 µg

MIR183 Rat MicroRNA Expression Plasmid (MI0000928)

Ask
View Details