Cyclopeptide-5

Cyclopeptide-5 (EMD 270179) is an αvβ3 antagonist that can improve PAF-induced increased adhesion of sickle red blood cells, capillary post-obstruction, and enhance blood flow dynamics. Cyclopeptide-5 also has cytotoxic effects[1][2].

Product Specifications

CAS Number

[197172-76-2]

Product Name Alternative

EMD 270179

UNSPSC

12352209

Hazard Statement

H302-H315-H319-H335

Target

Integrin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cyclopeptide-5.html

Smiles

O=C1C2(CCCCC2)NC([C@H](NC([C@@H](NC(CNC([C@@H](N1)CCCNC(N)=N)=O)=O)CC(O)=O)=O)CC3=CC=CC=C3)=O

Molecular Formula

C28H40N8O7

Molecular Weight

600.67

Precautions

P261-P280-P302+P352

References & Citations

[1]M Abo-Ghalia, et al. Synthesis and investigation of a new cyclo (Nalpha-dipicolinoyl) pentapeptide of a breast and CNS cytotoxic activity and an ionophoric specificity. Amino Acids. 2004 Jun;26 (3) :283-9.|[2]Eileen M Finnegan, et al. Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion. Am J Physiol Heart Circ Physiol. 2007 Aug;293 (2) :H1038-45.