Neoseptin-3

Neoseptin-3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist (EC50 of 18.5 μM). Neoseptin-3 stimulates the activity of mouse TLR4 (mTLR4)/myeloid differentiation factor 2 (mTLR) independently of CD14 (cluster of differentiation 14). Neoseptin-3 binds to MD2, changes the conformation of MD-2 and facilitates active TLR4/MD-2 dimer formation.