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Notch1 Rabbit Monoclonal Antibody

Anti-Notch1 Monoclonal Antibody. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Product Name Alternative

Signal transducer and activator of transcription 3; Acute-phase response factor; STAT3; APRF

UniProt

P46531

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Notch1 Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.

Target

Neurogenic locus notch homolog protein 1

Clonality

Monoclonal

Clone

BDICX36

Conjugation

Unconjugated

Field of Research

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Neuroscience, Stem Cell & Developmental Biology

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Dilution

WB 1:500-2000 IHC 1:50-200 ICC/IF 1:50-200 FC 1:50

Form

Liquid

Molecular Weight

110 kDa

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Tested Applications

FC, ICC, IF, IHC, WB

Host or Source

Rabbit

Preservative

Rabbit IgG in stabilizing components, phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. *This antibody is supplied in a stabilized formulation. Compatibility with conjugation reactions depends on the chemistry of the conjugation method used. For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Isotype

Rabbit IgG

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