Vazegepant
Product Specifications
UNSPSC Description
Vazegepant (Zavegepant) is an orally active calcitonin gene-related peptide CGRP receptor antagonist with potential for acute research in migraine, can be administered intranasally. CGRP is an important trigger in migraine pathophysiology[1][2][3][4].
Target Antigen
CGRP Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vazegepant.html
Smiles
O=C(N1CCC(C2=CC3=C(NC2=O)C=CC=C3)CC1)N[C@H](CC4=CC5=C(NN=C5)C(C)=C4)C(N6CCN(C7CCN(C)CC7)CC6)=O
Molecular Weight
638.80
References & Citations
[1]Leonard KA, et al. Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2020 Mar 26;63(6):2915-2929.|[2]Gene M Dubowchik, et al. Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success.|[3]Capi M, De Angelis V, De Bernardini D, et al. Zavegepant[M]//Novel Synthetic Drugs in Migraine. Cham: Springer International Publishing, 2022: 67-72.|[4]Jéssica Barreto Ribeiro Dos Santos, et al. Small-molecule CGRP receptor antagonists: A new approach to the acute and preventive treatment of migraine. Eur J Pharmacol.2022 May 5:922:174902.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-134992/Vazegepant-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-134992/Vazegepant-SDS-MedChemExpress.pdf
CAS Number
1337918-83-8
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
IRTAMSCD4GK15CAPC200 200 Tests
Anti Mouse CD4 Flow Cytometry Monoclonal Clone GK15 APC Ready To Use 200 Tests
Ask
View Details TA807088AM 100 µL
APOB48R (APOBR) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3D11]
Ask
View Details ![Rabbit Polyclonal NLE1 Antibody [Janelia Fluor 646]](https://cdn.genprice.uk/genprice/genprice5.png)