Ammonium chloride, AR, 99.5%
Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Ammonium chloride is also a lysosome inhibitor[1][2][3].
Product Specifications
CAS Number
[12125-02-9]
UNSPSC
12352200
Hazard Statement
H302, H319
Target
Autophagy
Type
Biochemical Assay Reagents
Related Pathways
Autophagy
Applications
COVID-19-anti-virus
Field of Research
Cancer
Purity
99.99
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
[NH4].[Cl]
Molecular Formula
NH4Cl
Molecular Weight
53.49
Precautions
H302, H319
References & Citations
[1]Huang X, et al. NH4Cl treatment prevents doxorubicin-induced myocardial dysfunction in vivo. Life Sci. 2019;227:94-100. |[2]Canning WM, Fields BN. Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells. Science. 1983;219 (4587) :987-988. |[3]Yu C, et al. Lysosome dysfunction enhances oxidative stress-induced apoptosis through ubiquitinated protein accumulation in Hela cells. Anat Rec (Hoboken) . 2013 Jan;296 (1) :31-9.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
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Scientific Category
Biochemical Assay Reagents
Clinical Information
Launched
Citation 01
Acta Pharm Sin B. 2021 Sep;11 (9) :2850-2858.|Adv Sci (Weinh) . 2025 Jun 29:e09533.|Adv Sci (Weinh) . 2025 Oct 22:e07602.|Antiviral Res. 2023 Jun:214:105606.|Aquaculture. 2025 Feb 15.|Autophagy. 2025 Aug 28:1-15.|Autophagy. 2025 Aug;21 (8) :1644-1661.|Biochem Pharmacol. 2018 Apr:150:280-292.|Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Apr 26:159618.|Cell Death Differ. 2025 Apr 8.|Cell Death Differ. 2025 Jun;32 (6) :1041-1057.|Cell Death Differ. 2025 May 20.|Cell Death Dis. 2024 Sep 11;15 (9) :665.|Cell Rep. 2025 Apr 2;44 (4) :115489.|iScience. 2024 Mar 12;27 (4) :109497.|J Immunol. 2025 May 30:vkaf118.|J Leukoc Biol. 2025 Jun 23:qiaf095.|J Virol. 2025 May 22:e0034725.|Nat Commun. 2024 Jul 18;15 (1) :6043.|Nat Commun. 2025 Jan 2;16 (1) :339.|PLoS Pathog. 2024 Feb 14;20 (2) :e1011981.|Research Square Preprint. 2023 Jun 22.|Signal Transduct Target Ther. 2024 Dec 30;9 (1) :367.|Vet Res. 2025 Apr 23;56 (1) :87.|Vet Res. 2025 Feb 28;56 (1) :46.|Virol J. 2022 Sep 20;19 (1) :151.|Viruses. 2019 Dec 30;12 (1) :43.|Adv Sci (Weinh) . 2025 Aug 4:e04680.|Adv Sci (Weinh) . 2025 Nov 7:e18323.|Aquaculture. 2025 Oct 15.|bioRxiv. 2024 November 19.|bioRxiv. 2025 Sep 6.|Cancer Lett. 2025 Apr 10:217715.|Cell Rep. 2025 Feb 19;44 (3) :115339.|Eur J Med Chem. 2025 Jun 14:296:117871.|MedComm (2020) . 2025 Aug 31;6 (9) :e70353.|PLoS Pathog. 2025 Jul 16;21 (7) :e1013344.|SSRN. 2025 Sep 30.
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