Gly-Pro-pNA (hydrochloride)

Gly-Pro-pNA hydrochloride is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV) . Gly-Pro-pNA can be used to screen for DPP IV inhibitors. Gly-Pro-pNA hydrochloride can be studied as an experimental antidiabetic agents[1][2].

Product Specifications

CAS Number

[103213-34-9]

Product Name Alternative

2'-3'-Cyclic GMP-AMP-d8 (ammonium),2'-3'-cyclic GMP-AMP (sodium)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dipeptidyl Peptidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/gly-pro-pna-hydrochloride.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(N1CCC[C@H]1C(NC2=CC=C(C=C2)[N+]([O-])=O)=O)CN.Cl

Molecular Formula

C13H17ClN4O4

Molecular Weight

328.76

Precautions

H302, H315, H319, H335

References & Citations

[1]Kim YB, et al. Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118) . Arch Biochem Biophys. 2006;445 (1) :9-18.|[2]R. N. Kushwaha., et al., Discovery of 17 Gliptins in 17-Years of Research for the Treatment of Type 2 Diabetes: A Synthetic Overview. Journal of Diabetes Mellitus, 2014.