Lepidiline A

Lepidiline A exhibits cytotoxic activity against HL-60 cells with an IC50 value of 32.3 μM. Lepidiline A targets HSD17B1 activity, increases the bioconversion efficiency of sex hormones (including the conversion of estrogen into 17β-estradiol and 4-androsten-3,7-dione into testosterone), thereby improving the reproductive capacity of fruit flies.[1][2].

Product Specifications

CAS Number

[596093-98-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

17β-HSD

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lepidiline-a.html

Concentration

10mM

Purity

99.54

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CC1=C(C)[N+](CC2=CC=CC=C2)=CN1CC3=CC=CC=C3.[Cl-]

Molecular Formula

C19H21ClN2

Molecular Weight

312.84

Precautions

H302, H315, H319

References & Citations

[1]Mlostoń G, et al. Synthesis and Cytotoxic Activity of Lepidilines A-D: Comparison with Some 4,5-Diphenyl Analogues and Related Imidazole-2-thiones. J Nat Prod. 2021 Nov 22.|[2]Cheng C, et al. Lepidiline A Improves the Balance of Endogenous Sex Hormones and Increases Fecundity by Targeting HSD17B1. Mol Nutr Food Res. 2020 May;64 (10) :e1900706.