2-Chloro-ATP (sodium)
Product Specifications
UNSPSC Description
2-Chloro-ATP sodium (2-Chloro ATP) is an adenine nucleotide and an analog of ATP. It is an antagonist of the purinergic P2Y1 receptor and inhibits intracellular calcium mobilization induced by ADP (HY-W010918) in Jurkat cells expressing the human receptor (Ki=2.3 μM). 2-Chloro-ATP sodium is an agonist of the purinergic P2X receptor and induces inward currents in HEK293 cells expressing human bladder smooth muscle or rat PC12 forms of the receptor (EC50=0.5 and 2.5 μM). 2-Chloro-ATP sodium induces relaxation of precontracted guinea pig cecal strips in a concentration-dependent manner. 2-Chloro-ATP sodium has been used to study the substrate specificity of cyclic nucleotide-dependent protein kinases such as protein kinase A (PKA) and PKG.
Target Antigen
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/2-chloro-atp-sodium.html
Smiles
O[C@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](O[P](O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)([H])N2C3=NC(Cl)=NC(N)=C3N=C2
Molecular Weight
629.55
References & Citations
[1]Satchell, et al. Inhibitory effects of adenine nucleotide analogs on the isolated guinea-pig taenia coli. J. Pharmacol. Exp. Ther. 195(3), 540-548 (1975).
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-137325A/2-Chloro-ATP-sodium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-137325A/
Clinical Information
No Development Reported
CAS Number
301334-89-4
Curated Selection
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