Neurokinin Receptor (393-407), rat

Neurokinin Receptor (393-407), rat (SPR393–407) is a rat neurokinin 1 receptor (NK1R) fragment. NK1R is rapidly internalized by endocytosis and recycled to the plasma membrane when binding to substance P (SP) . Neurokinin Receptor (393-407), rat can be used in the research of neurogenic inflammation[1][2].

Product Specifications

CAS Number

[153607-26-2]

Product Name Alternative

SPR393-407

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/neurokinin-receptor-393-407-rat.html

Solubility

10 mM in DMSO

Smiles

OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CCSC)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)NC([C@@H](NC([C@H](CO)NC([C@H](CO)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CCSC)NC([C@H]([C@H](O)C)NC([C@@H](N)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O

Molecular Formula

C72H113N17O26S2

Molecular Weight

1696.90

References & Citations

[1]Nathan JD, et al. Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2001 Nov;281 (5) :G1322-8. |[2]Vigna SR, et al. Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells. J Neurosci. 1994 Feb;14 (2) :834-45.