L-779450
L-779450 is a potent and selective B-Raf kinase inhibitor with a Kd of 2.4 nM.
Product Specifications
CAS Number
303727-31-3
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
Autophagy; Raf
Type
Reference compound
Related Pathways
Autophagy; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/L-779450.html
Purity
98.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC(C2=C(C3=CC=NC=C3)N=C(C4=CC=CC=C4)N2)=CC=C1Cl
Molecular Formula
C20H14ClN3O
Molecular Weight
347.80
Precautions
H301, H315, H319, H335
References & Citations
[1]Takle AK, et al. The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 1;18 (15) :4373-6.|[2]Shelton JG, et al. Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia. 2003 Sep;17 (9) :1765-82.|[3]Berger A, et al. RAF inhibition overcomes resistance to TRAIL-induced apoptosis in melanoma cells. J Invest Dermatol. 2014 Feb;134 (2) :430-440.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf
Available Sizes
Frequently Asked Questions
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