L-779450

L-779450 is a potent and selective B-Raf kinase inhibitor with a Kd of 2.4 nM.

Product Specifications

CAS Number

[303727-31-3]

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

Autophagy; Raf

Type

Reference compound

Related Pathways

Autophagy; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/L-779450.html

Purity

98.75

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC(C2=C(C3=CC=NC=C3)N=C(C4=CC=CC=C4)N2)=CC=C1Cl

Molecular Formula

C20H14ClN3O

Molecular Weight

347.80

Precautions

H301, H315, H319, H335

References & Citations

[1]Takle AK, et al. The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 1;18 (15) :4373-6.|[2]Shelton JG, et al. Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia. 2003 Sep;17 (9) :1765-82.|[3]Berger A, et al. RAF inhibition overcomes resistance to TRAIL-induced apoptosis in melanoma cells. J Invest Dermatol. 2014 Feb;134 (2) :430-440.