IGF-1 (M23), CF594 conjugate, 0.1mg/mL
This antibody is specific to Insulin-like Growth Factor (IGF-1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF-1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product Specifications
Synonyms
Insulin-like Growth Factor IA (IGF-IA) ; Insulin-like Growth Factor IB (IGF-IB) ; Mechano Growth Factor (MGF) ; Somatomedin-C
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
IGF1
Gene ID
3479
NCBI Gene ID
160562
UniProt
P05019
Swiss Prot
P05019
Host
Mouse
Species Reactivity
Human,Mouse,Rabbit,Rat
Reactivity
IGF-1
Immunogen
Purified human IGF-1 protein
Target Antigen
IGF-1
Clonality
Monoclonal
Clone
M23
Type
Primary
Source
Animal
Origin
Animal
Applications
IHC, FFPE (published) |WB (published)
Field of Research
Cancer, Signal transduction
Positive Control
Pancreas or brain. Breast, Thyroid or Colon Cancers; IGF-1 recombinant protein
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% BSA, 0.05% azide
Molecular Weight
~7.6 kDa
References & Citations
Note: References for this clone sold by other suppliers may be listed for expected applications. In Vivo (2009) 23: 567-576. (IHC, FFPE; WB)
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Product Datasheet
https://cdn.gentaur.com/products/37/883179/datasheet/bnc940220-500.pdf
Product MSDS
https://cdn.gentaur.com/products/37/68dd029c061270361e1023fd/msds/bnc940220-500.pdf
Fragment
IgG1, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
0.05% sodium azide (CAS 26628-22-8)
CAS Number
9007-83-4
Conjugate
CF594
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