2-Hydrazinobenzothiazole

2-Hydrazinobenzothiazole is a potent IDO1 inhibitor with an IC50 of 8 μM. 2-hydrazinobenzothiazole interacts with the IDO1 haem through hydrazine. 2-hydrazinobenzothiazole has the potential for immune system related diseases research[1].

Product Specifications

CAS Number

[615-21-4]

UNSPSC

12352005

Hazard Statement

H301, H315, H319

Target

Indoleamine 2,3-Dioxygenase (IDO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/2-hydrazinobenzothiazole.html

Purity

99.95

Solubility

DMSO : ≥ 100 mg/mL

Smiles

NNC1=NC2=CC=CC=C2S1

Molecular Formula

C7H7N3S

Molecular Weight

165.22

Precautions

H301, H315, H319

References & Citations

[1]Sai-Parng S Fung, et al. Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1) . Bioorg Med Chem. 2013 Dec 15;21 (24) :7595-603.