EGFR kinase inhibitor 4
EGFR kinase inhibitor 4 (Compound 4) is a bivalent ATP-allosteric EGFR inhibitor (IC50: 1.8 nM for mutant EGFR (LRTMCS) ) . EGFR kinase inhibitor 4 can be used for research of NSCLC[1].
Product Specifications
CAS Number
2922402-05-7
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-kinase-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC(C2=C(NC(CC)=N2)C3=CC=NC(NC4=C(OC)C=CC(NC(C=C)=O)=C4)=C3)=C1)C5=C6NC(C7=C(NC6=CC=C5)C=CC=C7)=O
Molecular Formula
C40H34N8O4
Molecular Weight
690.75
References & Citations
[1]Wittlinger F, et al. Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Commun Chem. 2024 Feb 20;7 (1) :38.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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