MAO-A/B-IN-3

MAO-A/B-IN-3 (Compound 12) stands out as a key dual MAO-AChE inhibitor, displaying excellent multi-target efficacy against MAO-A, MAO-B, and AChE with IC50 values of 67 nM, 29 nM, and 1370 nM respectively. MAO-A/B-IN-3 is adept at altering the A site (hydrophobic ring) and C site (semicarbazone chain) within ketone amine-based MTDLs to bolster the inhibitory potential against MAO-A/B while notably diminishing activity against AChE. MAO-A/B-IN-3 is poised for research applications in the field of neurodegenerative diseases[1].

Product Specifications

CAS Number

[315210-31-2]

UNSPSC

12352005

Target

Cholinesterase (ChE) ; Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mao-a-b-in-3.html

Smiles

O=C(N/N=C(C1=CC=C(O)C=C1)\C)CN(C=N2)C3=C2C=CC=C3

Molecular Formula

C17H16N4O2

Molecular Weight

308.33

References & Citations

[1]Kumar S, et al. Benzimidazole-derived carbohydrazones as dual monoamine oxidases and acetylcholinesterase inhibitors: design, synthesis, and evaluation[J]. Journal of Biomolecular Structure and Dynamics, 2023: 1-20.